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Individuals with a history of gastrointestinal disorders, such as ulcers or inflammatory bowel disease, or chronic diseases such as liver or kidney disease are at higher risk of developing Melaena

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Phase IIb ran to 24 weeks without reported safety signals

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Katayama et al., screened 32 flavonoids, out of which 20 compounds (including acacetin, apigenin, chrysin, diosmin, luteolin, luteolin-4-O-glucoside, 3,4,7-trimethoxyflavone, to name a few) were found to impede the breast cancer resistance protein, amongst them, 3,4,7-trimethoxyflavone exerted the most potent inhibitory activity against breast cancer resistance protein