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It is likely that CCK-1R signaling activates vagal afferents at least partly via PKA, as (1) CCK-1R activation increases cyclic adenosine monophosphate 197 , (2) PKA is necessary for CCK to activate central afferent terminals 172 , and (3) duodenal PKA activation leads to vagal afferent firing 196

In fact, the impact of psychological changes, pain, and suffering should also be considered, but this is largely absent in most existing research 30

Gerstein 1999

Specifically, the FDA considered claims that compounded products are generic versions or contain the same active ingredient as FDA-approved GLP-1 drugs are false or misleading

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