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What published clinical research shows: The STEP-1 trial (semaglutide, published in NEJM 2021) demonstrated that participants with obesity or overweight without diabetes who received semaglutide 2.4 mg weekly plus lifestyle intervention experienced mean weight loss of 14.9% over 68 weeks
10.2337/diacare.16.8.1167 26 GrantP.LipscombD.QuinJ
The effect of immediate release and extended release metformin on A1c levels is similar (55)
For those already on a GLP-1 and worried about experiencing the inevitable shed, the first thing to do is remember that this is a normal side effect (to a degree) and it doesnt mean you should abandon ship on your GLP-1
In this regard, we have a relevant body of evidence
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