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Clinical data shows average weight loss of 5-10% of body weight in the first three months, which translates to roughly 10-25 pounds for someone weighing 200 pounds, depending on starting weight and individual response factors

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Specifically, we previously reported similar expression profiles showing transcriptional repression of Igfbp3 and Igfbp5 after different challenges in IGF1R-deficient lungs [21,22,23, 37]