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A new and emerging issue is the development of profound insulin deficiency associated with the use of immune check-point inhibitors, which may present with hyperglycaemia and diabetic ketoacidosis (DKA) [4]

Most people have lost 10% to 15% by the six-month mark

Diabetic mice have altered mitochondrial function in the myocardium earlier than in the kidney, brain, and liver

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However, due to some side-effects, the role and mechanism of action of KD and BHB in the prevention and treatment of DKD are controversial