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A 2025 retrospective cohort study of 210 T2DM patients on oral semaglutide for 18 months found no significant association between rs6923761 or rs761387 genotypes and changes in HbA1c or BMI in that relatively well-controlled population (Candido et al., 2025) suggesting that receptor-level genotype effects may be detectable primarily in subpopulations with higher pharmacological demand or larger baseline disease severity, rather than as universal predictors

Fred Sattler at University of Southern California Keck School of Medicine

2017 Mar [cited 2019 May 26]

Semaglutide and other GLP-1 agonists actually improve glucose metabolism but work through appetite suppression rather than direct fat cell targeting