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Unconjugated NAPQI binds to proteins and subcellular structures and induces rapid cell death and necrosis that can lead to liver failure

Imatinib-induced GPX4 proteasomal degradation Imatinib is a tyrosine kinase inhibitor designed to inhibit BCR-ABL activity in chronic myelogenous leukemia (CML) that revolutionized the treatment of this hematopoietic malignancy in the early 2000s [46]

prausnitzii in CKD mouse models resulted in improved renal function by reducing renal inflammation and lowering the serum levels of various uremic toxins, which was partly attributed to the butyrate-mediated GPR-43 signaling in the kidney (Li et al., 2022)

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