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The majority of work investigating OS in autism has focused on peripheral markers, largely employing invasive and in vitro techniques

Indeed, numerous studies evidenced higher levels of PPA and other intestinal short-chain fatty acids in ASD subjects (94), initially used to study insulin resistance, diabetes-induced nephropathy, and phenylketonuria (95)

Antioxidants Resveratrol is a natural polyphenolic compound widely found in plants such as Polygonum cuspidatum and grapes

4.3 Branched-chain amino acid (BCAA) metabolism and DKD 4.3.1 Dietary BCAAs and insulin resistance Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, constitute approximately 15%20% of dietary protein (130)