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It is worth noting that our participants had a higher baseline BMI (mean 41.5 kg m 2 ) than in the STEP 1 trial (37.9 kg m 2 ), with some studies 24 showing that greater weight loss is observed with a higher baseline BMI, which may explain the greater %WL observed in our trial

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These symptoms often correlate with other gastrointestinal effects and typically improve as tolerance develops

Other Related Medications Medications like Mounjaro (tirzepatide) and Zepbound, although not semaglutide-based, work similarly as GLP-1 agonists and share similar side effect profiles