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Despite the well-established increase in IFP within breast tumors, our understanding of how breast cancer cells respond to this physical stimulus remains elusive due to the scarcity of reliable in vitro platforms that permit adjustment of pressure independent of changes in pH or the dissolved concentration of gases

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10 Conclusions and future directions While the existence of physical stimuli within the breast tumor microenvironment and throughout the metastatic cascade has been acknowledged for several decades, our understanding of their role in breast cancer remains incomplete

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