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Safety, Eligibility, and Who Should Consider This Approach Tirzepatide itself carries established safety monitoring: nausea, gastrointestinal side effects, and rare but serious risks like pancreatitis or thyroid concerns require provider oversight

Studies have also found that vitamin D supplementation can significantly reduce TPOAb levels (Chaudhary et al., 2016), suggesting that vitamin D may affect thyroid function via immunomodulation

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The neuroinflammatory and CGRP changes may resolve more slowly than the metabolic changes, providing a window of continued benefit