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Indeed, the expression of the GSTP1-1 variant Ile105Val is able to increase the effect of lead on the development of ASL 66

Glutathione is an important antioxidant in the lungs, but its concentration is low in the airways of patients with cystic fibrosis, since GSH is transported into the airways by the cystic fibrosis transmembrane conductance regulator, which is mutated in cystic fibrosis patients (111)

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