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Comparison of direct and indirect estimates Abbreviations AST aspartate aminotransferase CAP controlled attenuation parameter GLP-1RA glucagon-like peptide-1 receptor agonist 1 H-MRS proton magnetic resonance spectroscopy HOMA-IR homeostasis model assessment of insulin resistance NAFLD nonalcoholic fatty liver disease NAS nonalcoholic fatty liver disease activity score NASH nonalcoholic steatohepatitis RCT randomized controlled trial REFERENCES 1

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The particles were then auto-refined and Bayesian polished in Relion, followed by a non-uniform refinement in CryoSPARC (v 4.2.1) 41 with CTF refinement

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