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Researchers looked at insurance claims from 60,000 US patients, aged 1864 years with type 2 diabetes mellitus, who had taken liraglutide, semaglutide or tirzepatide between 2019 and 2025

In the TCA cycle, malate is stripped of its hydrogen atoms, which in the process generates NADH2

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The compound shows effectiveness across a wide dose range in animal studies (10 ng/kg to 10 mcg/kg producing comparable results), suggesting that more is not necessarily better

At 48 weeks, the least-squares mean percentage change in body weight in the retatrutide groups was -8.7% (1 mg), -17.1% (combined 4 mg), -22.8% (combined 8 mg), and an astounding -24.2% (12 mg), compared to -2.1% in the placebo group