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However with effective January 5, 2026 several states have moved to aggressively recalibrate their tobacco taxes

Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

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Born in 1946 20 years before the US surgeon general pronounced for the first time that cigarettes could cause cancer Lynch came up in a time when American glamor was buttressed by cigarettes and cinema

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