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GLP-1 AND GIP Given the extensive clinical experience with GLP-1 RAs and the established safety profile in cardiovascular disease settings, peptide multi-agonists have been developed to target multihormonal peptide-secreting enteroendocrine cells.8 Due to their glucose-lowering functions, the combination of GLP-1 and GIP hormones is one of the most attractive strategies for treating T2DM.8, 9 GLP-1 was first identified as a cleavage product of preproglucagon generated by L cells in the small intestine and functions to increase postprandial insulin production and lower blood glucose.10, 11, 12, 13 Since its discovery, efforts have focused on extending GLP-1 agonist activity through structural changes.14 Liraglutide and semaglutide, two long-acting GLP-1 RAs, have been authorized for the treatment of T2DM and obesity

Activating GIP alongside GLP-1 may enhance insulin sensitivity and the bodys handling of nutrients while reinforcing appetite suppression, and some evidence suggests the GIP component can help reduce the nausea burden relative to the degree of weight loss achieved

Program Includes: Supervised Monthly Check-ins with Nurse Practitioner Prescription Sent to Your Preferred Pharmacy (Discount cards available) Regular Weigh-ins and Medication Adjustments as needed Phentermine is not suitable for patients with heart disease, high blood pressure, glaucoma, overactive thyroid, or women who are pregnant, breastfeeding, or may become pregnant

Slower gastric emptying means nutrients are absorbed more gradually, which blunts post-meal glucose spikes and contributes to prolonged feelings of fullness

Food and Drug Administration-approved (FDA-approved) for the treatment of type 2 diabetes and has an additional indication for reducing the risk of major cardiovascular events, such as heart attack or stroke in individuals with type 2 diabetes and cardiovascular disease