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The retrospective analysis showed that newer-generation agents like semaglutide and tirzepatide offered the most substantial benefits when used for at least 3 years, suggesting that GLP-1s provide direct, disease-modifying, and anti-inflammatory activity within cartilage tissue

In the UK, Wegovy tablets are currently the first GLP-1 tablet licensed for weight management in eligible adults

In Jamess case, I discuss the unique physiology and risk architecture of adult-onset type 1 diabetes (positive GAD antibodies and unmeasurable C-peptide confirming beta-cell failure), the challenges of obesity in type 1 patients, and the layered burden of CKD and ischemic heart disease