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143 While some of these agents have demonstrated isolated positive findings, the overall evidence base remains insufficient, with most studies being limited by small sample sizes, methodological variability, or lack of replication

65 years]), clinical parameters (body mass index [BMI] categories: 2530 and 30 kg/m), and comorbid conditions (metabolic dysfunction-associated steatohepatitis [MASH], cirrhosis, heart failure, T2D, and CKD)

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Bennett et al., 2014