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Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig

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On the other hand, some literature suggests that L-carnitine, by promoting pyruvate oxidation, may accelerate carbohydrate breakdown, leading to rapid depletion of muscle glycogen and potentially producing a detrimental effect on exercise performance