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This leads to increased insulin production, decreased glucagon secretion, and delayed gastric emptying, which helps control blood sugar levels and reduce appetite

Metformin should be initiated unless (1) contraindications exist, (2) the A1C level indicates the need for insulin (at which time both insulin and metformin could be started), or (3) the A1C level is very close to goal (within 0.5% of goal) at the time of diagnosis and the patient is motivated to make appropriate lifestyle interventions

The gut microbiome in Parkinson's disease: a longitudinal study of the impacts on disease progression and the use of device-assisted therapies

Renal substrate exchange and gluconeogenesis in normal postabsorptive humans